Revista Chilena de Pediatría

Editorial

Carla Benaglio Vedovelli

595-598

Professionalism and care in the post-pandemic era: some reflections to think about the training of health professionals

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Topicality

Enrique Paris, María Isabel Hodgson, Gigliola Alberti, Mercedes Guevara, Mariana Calzada, Cecilia Baeza, Pascale Patri, María Verónica Bravo, Sandra Henríquez, Thiare Olguín, Natalia Zambrano, Bárbara Reyes, Raúl Escárate, Juan Pablo Moreno, Paula Cisternas

599-603

Chronic intestinal failure: challenges, comprehensive management, and the need for universal access to home parenteral nutrition

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Original articles

Mercedes Bernadá, Martin Notejane, Yessica Mena, Albertina Filardi

604-612

Therapeutic effort adequacy directives. Experience of a Pediatric Palliative Care Unit

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Diego Andrés Rodriguez Rangel, Laura Daniela Arenas Camacho, Nicolas Andres Quiroga Barrera, Angie Daniela Lizarazo, Zully Marley Navas Casas, Hugo Ferreira Traslaviña, Juan Carlos Uribe Caput

613-618

Incidence, evolution and clinical behavior of pseudocholelithiasis associated with ceftriaxone in children

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Tamara Velásquez Cárcamo, Carolina Méndez Benavente

619-627

Low levels of vitamin D at one month of age and its association with bronchopulmonary dysplasia in premature newborns under 32 weeks and/or under 1500 g

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Romina Espinoza Núñez, Carlos Valdebenito Parra, Antonio Huerta-Armijo, Francisco Prado Atlagic

628-635

Clinical complexity and need for palliative care in non-oncological patients with special health care needs

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Camila Cabrera Díaz, Claudio Gonzalez Muñoz, Giannina Izquierdo Copiz

636-644

Vancomycin is an antimicrobial widely used in hospitalized newborns (NB), with different dosing schedules that may or may not recommend the use of loading doses, depending on gestational age (GA), weight, and renal function. Objective: To evaluate the use of plasma levels after a vancomycin loading dose and its impact on achieving the target area under the curve/minimum inhibitory concentration (AUC/MIC) in a neonatal intensive care unit (NICU). Patients and Method: Retrospective, descriptive, and observational study in NBs hospitalized between December 2022 and December 2023, in a high-complexity NICU. All NBs with empiric/targeted vancomycin indication were included, who received loading doses with baseline plasma concentration (Pc) monitoring, according to local protocol. Demographic and clinical data were recorded. Renal failure was considered when creatinine increased by 0.3 mg/dl in 48 hours and/or urinary output ≤ 1 ml/kg/day. The PrecisePK® software was used to estimate pharmacokinetic parameters and the AUC. Results: 52 vancomycin Pc samples were analyzed, of which 73.1% reached optimal values between 10-20 mcg/ml, 19.2% Pc samples were supratherapeutic (> 20 mcg/ml), and 86% of patients achieved an AUC between 400- 600 mg/L. The main risk factor for supratherapeutic Pc was renal failure before treatment (p = 0.001). Conclusions: This study indicates that the loading dose of vancomycin achieves optimal AUC in 86% of cases. It is recommended to closely monitor with basal Pc following the administration of a loading dose, particularly in patients with renal failure

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Fernando Carvajal-Encina, Luciano Carvajal Rojas

645-653

Prevention of premature birth: Impact of the Explicit Health Guarantee

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Clinical cases

María Ximena Castro-García, Alejandro Restrepo-Cedeño, Luz Ángela Urcuqui-Bustamante, Pamela Andrea Rodriguez-Riveros, William Murcia-Rodríguez, Viviana Lotero-Díaz

654-660

Challenges in diagnosis of primary penile tumor of the endodermal sinus in infants

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Review articles

Jaime Cerda, Angélica Domínguez

661-667

Precautions regarding the calculation and interpretation of relative risk in pediatric studies

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Ingrid Leal Fuentes, Amanda Pey , Paulina

668-681

Exploring menstrual health in girls and adolescents: A scoping review

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Scientific Society Recommendation

Luisa Fernanda Rojas-Rosas, Richard Baquero Rodriguez, Juan Guillermo Cárdenas Aguilera, Diana Carolina Bello Márquez, Luz Mery Rivera Parra, Carolina Lucía Ochoa García, Carol Morales Contreras, Maria Claudia Prada, Cristiam Alexander Morales Castro, Martha Isabel Carrascal Guzmán, Kelly Rocío Chacón Acevedo, Maria Paula Gutiérrez Sepúlveda, Luz Beatriz Restrepo Palacio, Ángela Inés Ocampo Trujillo, Celeste Alston, Victor Hugo Figueroa, Liliana María Rubio Elorza, Jorge Alberto Martínez Montoya, Paula Mariela Carlopio, Ana María Castillo Fernández, Mariela Andrea Ríos, Julio Centurión, Cristian Roberto Sager

682-691

Clinical Guideline for the management of Neurogenic Bladder in population under 18 years of age. Part 2: Treatment

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Branch Recommendations

Catalina Le Roy Olivos, María Virginia Amézquita García, Paulina Bravo Jiménez, Alexa Puchi Silva, Paula Díaz Paredes, Bárbara Reyes Espejo, Paulo Valderrama Erazo, Philip Foster Uribe, Gerardo Weisstaub

692-704

Obesity treatment: recommendation from the Nutrition Branch of the Chilean Society of Pediatrics

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