Abstract
Objectives: To analyze the usefulness of a clinical questionnaire for the diagnosis of sleep disordered breathing in children with neuromuscular diseases.
Patients and Methods: A sleep questionnaire and a polysom-nography were performed in a cohort of 21 children (14 boys) with neuromuscular diseases. ROC analysis was used to assess the diagnostic accuracy of the questionnaire for diagnosing sleep disordered breathing compared with polysomnography.
Results: Median age was 10.7 years (2-17). According to polysomnography, 8 patients were classified as normal, 3 had primary snoring, 5 had central sleep apnea syndrome and 5 an obstructive sleep apnea syndrome. Eleven questionnaire's scores suggested sleep disordered breathing. The questionnaire's score showed a sensitivity of 75%, specificity of 60%, positive predictive value of 33% and negative predictive value of 90% for the diagnosis of an obstructive sleep apnea syndrome. The same figure for the diagnosis of a central sleep apnea syndrome was 80%, 64%, 44% and 90%.
Conclusions: The questionnaire showed a moderate sensitivity and specificity. Nevertheless, the high negative predictive value of the questionnaire may support its use for screening of sleep disordered breathing. A follow-up of questionnaire's scores may identify patients, who would benefit from performance of polysomnography.
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