Effectiveness of early systemic inflammatory indices in predicting advanced intraventricular hemorrhage in preterm infants

Abstract

Objective: Some systemic inflammatory indices have been declared to be associated with intracerebral hemorrhage in adults. However, the relationship between systemic inflammatory indices and intraventricular hemorrhage (IVH) in premature infants is not yet fully known. In the present study, we aimed to evaluate the relationship between systemic inflammatory indices obtained on the first day of life in premature infants and the development of severe IVH.

Patients and method: Preterm infants <32 weeks of gestational age were included in the study. All eligible infants were divided into 2 groups as non-IVH, grade I and II hemorrhage (Group 1) and grade III and IV (advanced) IVH (Group 2). Demographic features, clinical outcomes, monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and systemic inflammation response index (SIRI) were compared between groups.

Results: A total of 1176 infants, 1074 in Group 1 and 102 preterm infants in Group 2, were included in the study. There was no difference between the groups in terms of leukocyte, neutrophil, monocyte, lymphocyte, and platelet count (p>0.05). NLR, MLR, PLR, PIV, SII, and SIRI values were similar in both groups (p>0.05).

Conclusion: While the relationship between inflammation, hemodynamics and IVH is still being discussed.  Our results showing that systemic inflammatory indices have no predictive value for IVH may cause a new discussion.