Abstract
Background: Qbesity is a disease characterized by an abnormal accumulation body fat that results in neuroen-docrine changes that alter the homeostasis of sodium, producing an increased risk of hypertension in adulthood.
Objective: To evaluate the effect of obesity on urinary sodium excretion in children and adolescents.
Subjects and Methods: 266 male and female children in the age group of 5-15 years were studied: 154 obese (OB) with > 95th percentile of BMI, and 112 normal-weight patients (C) with percentile 5-85 of BMI, from the outpatient service of the Children Hospital, Posadas, Misiones, Argentina during the years 2008 -2009. The determinations of serum sodium (Nas) and 24-hour urine (Naur) were performed using Ion Selective Electrode. The fractional excretion of sodium (FENa %) was calculated.
Results: Naur values (mEq/kg/day) and FENa % reported significantly lower differences in the obese group compared to controls: OB Naur 2.23 vs C Naur 3.40 (p < 0.0001); OB FENa % 0.59 vs C FENa % 0.71 (p = 0.001).
Conclusion: Results obtained in the present study showed that obese children have a significantly decreased urinary sodium excretion compared to normal weight children. This difference could be caused by renal retention of this ion.
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