Maternal immune activation and risk of Autism Spectrum Disorder
Vol. 90 No. 5 (2019), Continued Education
Vol. 90 No. 5 (2019)

Maternal immune activation and risk of Autism Spectrum Disorder

Continued Education
https://doi.org/10.32641/andespediatr.v90i5.1446
Published 2019-10-07
Carolina Heresi Venegas
Universidad de Chile; Hospital de niños Dr. Roberto del Río
https://orcid.org/0000-0002-0689-5859
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Keywords

Autism
Neurodevelopment
Maternal Immune Activation
Mental Health
Pregnancy
Autism Spectrum Disorder

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Heresi Venegas C. Maternal immune activation and risk of Autism Spectrum Disorder. Andes pediatr [Internet]. 2019 Oct. 7 [cited 2025 Sep. 12];90(5):555-8. Available from: https://andespediatrica.cl/index.php/rchped/article/view/1446
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Abstract

Autism Spectrum Disorder (ASD) etiology has been related whit complex interaction between genetic and environmental factors. In the last years, numerous studies have suggested that maternal immune activation during pregnancy could be related to ASD in the offspring. This relation could be explained by the effects of pro-inflammatory cytokines, autoantibodies and microglial synaptic pruning during early embryonic development. Better understanding of Neurodevelopmental Disorders risk factors will support appropriate strategies of screening and management of risk population.

https://doi.org/10.32641/andespediatr.v90i5.1446
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